ONE-FLOW – The Compartmentalized, Green-Solvent ‘Digital Synthesis Machinery’

FET open awarded project ONE-FLOW aims for a radically new, groundbreaking way to make process chemistry. The chemical industry conducts chemistry in multiple steps employing considerable separation methods, which require massive amounts of energy and solvents. But, Nature does chemistry differently! By mimic nature processes we will be able to reduce the energy consumption and the environmental impact of them.

ONE-FLOW has massive impact potential for reducing multistep organic synthesis from multiple steps to one operation.

ONE-FLOW translates ‘vertical hierarchy’ of chemical multistep synthesis with its complex machinery into self-organising ‘horizontal hierarchy’ of a compartmentalized flow reactor system – a biomimetic digital flow cascade machinery with just one reactor passage. To keep horizontal hierarchy manageable, orthogonality among the consecutive reactions needs to be increased. The winning point of nature is to have invented catalytic cascades. ONE-FLOW will uplift that by enabling the best bio- and chemocatalysts working hand in hand. 4 synthetic flow cascades driven by automated intelligence ('signaling pathway') will produce 4 Top-list 2020 drugs. We like to minimise the use of non-green solvents, even eliminate solvents completely, and use switchable green solvents, where functionality is requested (‘Spaciant Factory’). For more information please check: www.one-flow.org